Television workHelms was performing comedy in New York City when, as he recalled in a 2005 interview, "The Daily Show had a sort of open audition with a casting company that I had dealt with. I read for the part, and got it". In his April 2002 to mid-2006 tenure on the satirical news program, Helms contributed "field reports" in addition to hosting various segments of the show, such as Digital Watch, Ad Nauseam, and Mark Your Calendar. He has also contributed to the This Week in God segment. Helms left the show in 2006, but has occasionally returned for brief appearances. On July 21, 2008 he returned for Obama Quest – a segment covering then-Senator Barack Obama's trip to Iraq. He occasionally narrates the Prescott Group educational films on sister series The Colbert Report.

In late July 2006 NBC announced that Helms would join the cast of the mockumentary The Office, along with his fellow The Daily Show correspondent Steve Carell, in a recurring role as Andy Bernard. Helms has been a series regular since the third season.

Helms returned to The Daily Show on December 5, 2006, stating he had been gone because he was "undercover at a paper company in Scranton", an allusion to his stint on The Office. In February 2007, NBC announced that Helms had been promoted to series regular, and in February 2010 Helms was added to the show's opening credits. In June 2009, on a radio interview with National Public Radio, Helms said that like his character, Andy Bernard, he is obsessed with a capella music.

Helms has appeared on such television shows as Tanner on Tanner, Childrens Hospital, Arrested Development and Cheap Seats, and in various Comedy Central specials. He has done commercial voiceover work in campaigns for Burger King, Doritos, Hotels.com, Sharp Aquos and Advair asthma medication, and he voices Angel, a character on Cartoon Network's Weighty Decisions series.

Helms plays guitar, banjo (which was shown in the commercial bumpers and on a What Up With That? sketch when he hosted Saturday Night Live in 2011), and piano, and he has played all three, as well as a sitar, in some of his movies and television performances.

[edit] Film workHelms starred in the 2011 film Cedar Rapids and co-starred in the blockbuster 2009 film The Hangover. He previously appeared in small roles in films including Night at the Museum: Battle of the Smithsonian, Blackballed: The Bobby Dukes Story, Meet Dave, Harold & Kumar Escape from Guantanamo Bay, I'll Believe You, Evan Almighty, Semi-Pro and, with Office co-star Jenna Fischer, Walk Hard: The Dewey Cox Story. In 2009, Helms appeared in The Goods: Live Hard, Sell Hard, directed by Neal Brennan and starring Jeremy Piven.

Helms has been developing, with Judd Apatow, a Universal Pictures film, A Whole New Hugh, in which he would star, and which he would co-write with Jake Fleisher and Ian Berger. Variety reported in February 2009 that Helms would star and he and Fleisher would co-write a Warner Bros. feature about a time-traveling Civil War re-enactor, with the film to be produced through The Office star Steve Carell's production company Carousel. Helms reprised his role in 2011's The Hangover Part II.

Other work
Helms is also in a band called "The Lonesome Trio" with his friends Ian and Jake. They formed the band when they were in college, and still get together to play a few shows every year.

(Profile information sourced from Wikipedia and other publicly available internet sources.)